In Ayurveda, health is defined as a state when all the physical systems and functions, and the soul and mind are harmoniously balanced. According to Ayurveda, the root cause of any disease is always the imbalance of tridoshas, or body humors. This further manifests as imbalance in other body components inevitably leading to disease. 

Without the imbalance of tridosha, the disease process cannot commence. Let us find out what causes this imbalance and leads to disease.

Three Causative Factors 
There are a variety of factors that causes disease. However these can all be categorized according to three main causes identified by Caraka. These are the improper use of the intellect (prajanaparadha), improper contact of the senses with their respective objects (asatmendriyartha samyoga) and seasonal variations (kala or parinama). These factors can all lead to conditions where disease can be generated, as they create an imbalance in the tridosa.

These three causes relate to mental, physical and environmental factors. As long as these factors are balanced, the dosas are balanced and disease cannot be generated. Disease can be manifested when the casual factors become unbalanced, which can occur due to three reasons: an excessive (atiyoga), deficient (hinayoga or ayoga) or incorrect (mithyayoga) action or situation. These concepts are clarified in the following pages.

Misuse of intellect—prajnaparadha
Prajna means "wisdom" or "intelligence", and apradha means "offence". So the literal meaning of prajnaparadha is "an offence against wisdom". That is, doing things without discriminating as to whether it is favorable or harmful for the body or mind. These actions may be verbal, mental or physical. The actions generated by prajnaparadha aggravate the tridosa and stimulate the rajas and tamas gunas, allowing diseases to become established.

Excessive/ atiyoga forms of this include talking too much, or excessive thinking, reading, mental work or physical activity. A deficiency (hina- yoga) of these actions is not undertaking these activities sufficiently, like not speaking at all or very little, and not working or engaging in any intellectual or physical activity.

Incorrect (mithya yoga) forms include gossip, lying, inciting violence and irrelevant, illogical or harsh speech. Actions that are motivated by greed, anger, material attachment, envy, ego, fear, grief or delusion also are mithya-yoga. The physical form of this includes the suppression of natural urges or performing unnatural activity such as smoking cigarettes, driving recklessly or participating in dangerous sports.

In brief all actions that impact on the body- mind in a negative way are mithya- yoga. The person has not considered the is aware of the potential dangers, but ignores these and proceeds to engage in those activities anyway. Examples include smoking cigarettes despite health warnings on the packet , or continuing to drink alcohol excessively even though negative effects may have been experienced many times before.

Misuse of senses—asatmendriyartha samyoga
Astmaya means "improper", indriya means "sense organs", artha is "the objects of the senses" and samyoga means "to combine" or "to link". Asatmendriyartha samyoga refers to improper contact of the senses with their objects, and results in an over stimulation or deficiency of ssensory activity. This harms the body- mind, which requires moderation and harmony internally and externally for healthy functioning .

Seasonal variations—parinama or kala 
The external envirorment can trigger disease by unbalancing the body through unnatural or extreme variations in temperature, rainfall or wind. Excessive or atiyoga of parinama is extraordinary or unexpected climatic conditions, such as excessive heat in summer or cold in winter. Deficient/ hina- yoga seasonal conditions include very mild temperature variations are not experienced. Incorrect/ mithya- yoga parinama occurs when conditions are opposite to the normal season, such as being cold in summer or warm in winter.

Parinama or kala also refers more generally to the effects of time, and natural physical transformation that occur over time. For example, seasonal influences on the dosas, and the disorders associated with specific phases of life and aging are all in this category.

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