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What is Ankylosing Spondylitis?
Ankylosing Spondylitis (AS) is a kind of arthritis that primarily affects the spine, but it can also target other joints like hips and shoulders. It's characterised by inflammation that can be quite painful. Over time, the inflammation can cause the spinal bones to fuse together, causing a stiff, hunched posture. This is more prevalent in males and mostly starts early in early adulthood.
The flexibility and mobility of the spine are affected as Ankylosing Spondylitis progresses, making daily activities difficult. The primary sign of Ankylosing Spondylitis is persistent pain and stiffness in the lower back and hips, particularly in the morning or after periods of inactivity.
There are basically two types of Ankylosing Spondylitis:
Axial spondyloarthritis radiographic: This is simply another name for Ankylosing Spondylitis and can be seen on X-rays where the sacroiliac joints (where the spine meets the pelvis) show signs of damage.
Non-radiographic axial spondyloarthritis: This type of Ankylosing Spondylitis presents the same symptoms as AS but does not show visible signs on X-rays, although inflammation can still be detected with other medical imaging tests.
Early diagnosis and treatment can help manage Ankylosing Spondylitis symptoms and slow down its progression. Ankylosing Spondylitis treatments may include herbal medication, various therapies and regular yoga and exercises to maintain joint function and ease pain. Knowing these types and their symptoms may help in seeking timely medical advice and treatment.
Common Causes of Ankylosing Spondylitis
Ankylosing Spondylitis (AS) is a complicated condition whose causes are associated with genetic factors, immune system activities and environmental factors. Knowing these triggers is essential for managing the disease and stopping its progression.
The following are the most common Ankylosing Spondylitis causes:
Genetic Factors
HLA-B27 Gene: A significant number of individuals with AS have the HLA-B27 gene. While having this gene does not necessarily mean that you will develop AS but it greatly increases the risk.
Family History: AS generally runs in families. If an immediate family member has AS, your risk is greater of developing the condition.
Immune System Dysfunction
Autoimmunity: AS is considered an autoimmune disease, where the immune system attacks bodily tissues accidentally, like the spinal column and sometimes other joints.
Environmental Triggers
Infections: Some bacterial infections, particularly in the intestines, have been associated with AS in genetically predisposed individuals.
Gut Microbiome: Recent findings suggest that changes in normal gut bacteria may play a role in triggering immune responses that lead to inflammation in the joint and spine.
Others Factors
Age: AS typically begins during late adolescence or early adulthood, usually before the age of 30.
Sex: Men are frequently and more severely affected by AS than women, suggesting potential hormonal influences on disease severity and progression.
Signs and Symptoms of Ankylosing Spondylitis
The onset of Ankylosing Spondylitis is generally subtle and can be mistaken as some other common back pains. However as the disease develops, these symptoms could become worse, impacting everyday activities and quality of life. Recognising Ankylosing Spondylitis symptoms early is important for timely diagnosis and treatment of the condition.
Listed below are the most noticeable Ankylosing Spondylitis symptoms:
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